Iodoethane → 2-(1-Ethylpiperidin-4-yl)ethan-1-ol

HRID 2403794Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2403794
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].I[CH2:17][CH3:18]>CN(C=O)C>[CH2:17]([N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][OH:9])[CH2:3][CH2:2]1)[CH3:18]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 739534-Piperidineethanol

Produkt 1

HCID 217027812-(1-Ethylpiperidin-4-yl)ethan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a stirring solution of 2-(4-piperidinyl)ethanol (Ig, 7.74 mmol) and potassium carbonate (2.67 g, 19.35 mmol) in dry DMF (10 ml) was added iodoethane (0.687 ml, 8.51 mmol). The reaction mixture was allowed to stir at room temperature for 18 hours. The solvent was partially removed in vacuo and the residue partitioned between water (20 ml) and ethyl acetate (20 ml). The aqueous was washed with further ethyl acetate and the combined organics dried (hydrophobic frit) and concentrated in vacuo to give the title compound as a mixture with residual DMF as a clear oil, 1.55 g

Aufarbeitung

  1. customThe solvent was partially removed in vacuo
  2. customthe residue partitioned between water (20 ml) and ethyl acetate (20 ml)
  3. washThe aqueous was washed with further ethyl acetate
  4. customthe combined organics dried (hydrophobic frit)
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3a90a7ce2fcf4602aeab94ba7a38f11f
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08802684B2

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