Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride

HRID 240384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 240384
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86680852Methyl 2-(pyrimidin-4-yl)benzoate

Produkt 1

HCID 866808532-(Pyrimidin-4-yl)benzoic acid hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-01408ecf25744b82a7ae5e5c745357b9
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648079B2

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