Formamide → HCID 178518013, Verbindung

HRID 240571

Reaktionsgleichung

Reaktionsgleichung von HRID 240571
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>O>[I:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:12][N:14]=[C:4]2[OH:5]

Komponenten

4

Edukt 2

HCID 713FormamideHCID 72911Benzoic acid, 2-amino-5-iodo-

Produkt 1

HCID 178518013HCID 178518013, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
190 °C

Versuchsvorschrift

A mixture of 2-amino-5-iodobenzoic acid (125 g, 475 mmol) and formamide (200 mL) was heated to 190° C. for 2 hours. After cooling to room temperature, the reaction mixture was poured into water (500 mL) and stirred for 2 hours. The solids were filtered and dried under high vacuum to provide the product (108 g, 83%).

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. filtrationThe solids were filtered
  3. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1cf203d6a8f34d2ea4d9ba40e1884b22
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648087B2

Verknüpfte Notizen

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