Hydrochloric Acid → HCID 57445190, Verbindung

HRID 2405839Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2405839
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][CH:12]([CH3:14])[CH3:13])[O:9][CH:10]=1)=[O:5])C.[OH-].[Na+].Cl>CCO.O>[CH:12]([NH:11][C:8]1[O:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1)([CH3:14])[CH3:13]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57445189HCID 57445189, Verbindung

Produkt 1

HCID 57445190HCID 57445190, VerbindungAusbeute 100,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To 2-isopropylamino-oxazole-4-carboxylic acid ethyl ester (2.5 g, 10.9 mmol) in EtOH (42 mL) and water (28 mL) was added NaOH (3.1 g, 77.4 mmol). The mixture was stirred at rt for 16 h, then cooled in an ice-bath and acidified to pH 3 with conc. HCl. The mixture was concentrated in vacuo to remove ethanol. The remaining aqueous phase was extracted with CH2Cl2 (3×200 mL). The organic phases were combined, dried over MgSO4 and concentrated to give 2-isopropylaminooxazole-4-carboxylic acid (1.86 g, 87% yield). LCMS found 171 [M+H]+.

Aufarbeitung

  1. temperaturecooled in an ice-bath
  2. concentrationThe mixture was concentrated in vacuo
  3. customto remove ethanol
  4. extractionThe remaining aqueous phase was extracted with CH2Cl2 (3×200 mL)
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-f7ff55c2f32748a4b007de6e97385a94
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809267B2

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