Water → 2-[1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-3-yl]ethanol

To a suspension of LiAlH4 (0.12 g, 3.16 mmol) in dry THF (4 ml) was added [1-(2,3-dihydrobenzo-[1,4]dioxin-2-ylmethyl)piperidin-3-yl]acetic acid ethyl ester 2.0 g (0.62 mmol) in dry THF (2 ml). The reaction mixture was refluxed for 1.5 h. Water was slowly added and the reaction mixture was extracted with EtOAc (3×20 ml). The combined organic phases were dried (Na2SO4), filtered and the filtrate was evaporated to give the desired product which was purified by column chromatography (EtOAc/heptane, 50:50).

1. temperatureThe reaction mixture was refluxed for 1.5 h
2. extractionthe reaction mixture was extracted with EtOAc (3×20 ml)
3. dry with materialThe combined organic phases were dried (Na2SO4)
4. filtrationfiltered
5. customthe filtrate was evaporated

ORD-Eintrag

ord-56af55a7382947f28d5c2e076987bc45

Quelldatensatz

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08809536B2