Sodium Azide → 4-(azidomethyl)tetrahydro-2H-pyran
Reaktionsgleichung
I[CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[N-:9]=[N+:10]=[N-:11].[Na+]>CS(C)=O.C(OCC)C>[N:9]([CH2:2][CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)=[N+:10]=[N-:11]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
4-(Iodomethyl)tetrahydro-2H-pyran (4.76 g, 21.1 mmol) was dissolved in dimethyl sulfoxide (25 mL). Sodium azide (2.70 g, 41.5 mmol) was added and the mixture was stirred at ambient temperature overnight. The resulting slurry was diluted with diethyl ether and washed with water. The organic layer was concentrated under reduced pressure to afford the title compound. The product was used directly in subsequent reactions without characterization.
Aufarbeitung
- washwashed with water
- concentrationThe organic layer was concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-36b0761f4dae4054b34f378061eef753
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08648069B2
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