Propargyl alcohol → [3-(2-Chlorophenyl)-1,2-oxazol-5-yl]methanol

HRID 2407657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2407657
C(N(CC)CC)C.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](Cl)=[N:16][OH:17].[CH2:19]([OH:22])[C:20]#[CH:21]>C(OCC)C>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[CH:21]=[C:20]([CH2:19][OH:22])[O:17][N:16]=1

Komponenten

5

Edukt 3

HCID 7859Propargyl alcoholHCID 8471TriethylamineHCID 38097332-Chloro-N-hydroxy-benzamidine

Produkt 1

HCID 1471845[3-(2-Chlorophenyl)-1,2-oxazol-5-yl]methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

A solution of triethylamine (48 mL) in diethyl ether (0.5 L) was added over two hours to a 0° C. solution of the compound prepared in Example 5 (50.0 g) and propargyl alcohol (31 mL) in diethyl ether (1.2 L). The reaction was stirred at room temperature overnight, washed with water, dried over anhydrous magnesium sulfate and concentrated to obtain the title compound (50.0 g) having the following physical data.

Aufarbeitung

  1. washwashed with water
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c57dba5bcf7c45099b8755f5405620f7
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809538B2

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