2-Chloronicotinic acid → 2-Ethoxypyridine-3-carboxylic acid

HRID 2407767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2407767
[O-:1][CH2:2][CH3:3].[Na+].Cl[C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9]>C(O)C>[CH2:2]([O:1][C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])[CH3:3]

Komponenten

4

Edukt 2

HCID 762582-Chloronicotinic acidHCID 2723922Sodium ethoxide

Produkt 1

HCID 27363452-Ethoxypyridine-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

A solution of sodium ethoxide (14.2 mL) was added to a solution of 2-chloronicotinic acid (2.00 g) in ethanol (13 mL). The mixture was heated in a sealed vessel at 170° C. for 2 days. After cooling, the mixture was concentrated in vacuo and the residue taken in water and acidified with hydrochloric acid to pH 3. The precipitated solids were collected by filtration and washed with water to obtain the title compound (1.32 g) having the following physical data.

Aufarbeitung

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo
  3. filtrationThe precipitated solids were collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-dc62b7633eaa408eb8d62e494388d43c
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809538B2

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