Tetrahydrofuran → 5-(4-Methoxyphenyl)-1,3,4-oxathiazol-2-one
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1.Cl[S:13]Cl.C1[CH2:19][O:18]CC1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]2[O:8][C:19](=[O:18])[S:13][N:9]=2)=[CH:5][CH:4]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
4-Methoxybenzamide (3.0 g, 19.9 mmol) was suspended in a mixture of toluene (30 mL) and THF (15 mL), and chlorosulfenyl chloride (3.35 mL, 39.7 mmol) was then added to the suspension. The obtained mixture was stirred at 80° C. for 2.5 hours. The reaction solution was cooled to room temperature, and it was then concentrated under reduced pressure. Thereafter, diethyl ether was added to the residue, and insoluble materials were then removed by filtration, so as to obtain the title compound (3.64 g, 88%) in the form of a colorless solid.
Aufarbeitung
- additionwas then added to the suspension
- temperatureThe reaction solution was cooled to room temperature
- concentrationit was then concentrated under reduced pressure
- additionThereafter, diethyl ether was added to the residue, and insoluble materials
- customwere then removed by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-a94f5d3b2c354ec1b946040e641dba93
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08648103B2
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