Water → 7'-Chloro-1'-(2-isopropoxyethyl)-spiro[cyclopentane-1,2'-imidazo[1,2-a]pyrimidin]-5'-one
Reaktionsgleichung
[Cl:1][C:2]1[N:3]=[C:4]2[NH:11][C:10]3([CH2:15][CH2:14][CH2:13][CH2:12]3)[CH2:9][N:5]2[C:6](=[O:8])[CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].CC1C=CC(S(O[CH2:33][CH2:34][O:35][CH:36]([CH3:38])[CH3:37])(=O)=O)=CC=1.O>CC#N.C(OCC)(=O)C>[Cl:1][C:2]1[N:3]=[C:4]2[N:11]([CH2:33][CH2:34][O:35][CH:36]([CH3:38])[CH3:37])[C:10]3([CH2:15][CH2:14][CH2:13][CH2:12]3)[CH2:9][N:5]2[C:6](=[O:8])[CH:7]=1Komponenten
7
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 65 °C
Versuchsvorschrift
0.200 g of 7′-chlorospiro[cyclopentane-1,2′-imidazo[1,2-a]pyrimidin]-5′-one are suspended in 7 mL of CH3CN, 0.70 g of cesium carbonate and 0.55 g of 2-isopropoxyethyl 4-methylbenzenesulfonate are added. The mixture is heated to 65° C. for 36 h. Water, ethyl acetate are added and then after decantation, the organic phase is dried with magnesium sulfate and then evaporated. The crude is purified by flash chromatography on silica gel (CH2Cl2/MeOH, 99/1). 0.17 g (yield=47%) of 7′-chloro-1′-(2-isopropoxyethyl)-spiro[cyclopentane-1,2′-imidazo[1,2-a]pyrimidin]-5′-one are obtained as a brown powder and including the following characteristics:
Aufarbeitung
- dry with materialafter decantation, the organic phase is dried with magnesium sulfate
- customevaporated
- customThe crude is purified by flash chromatography on silica gel (CH2Cl2/MeOH, 99/1)
Quellen und Nachweise
- ORD-Eintrag
- ord-cc8c1fc6f773474f8c6304a34e2b8d0d
- Quelldatensatz
- uspto-grants-2014_08
- Patentnummer
- US08815853B2
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