Acetic Acid → 2-Acetoxypropionic Acid

HRID 240893

Reaktionsgleichung

Reaktionsgleichung von HRID 240893
[OH:1][CH:2]([CH3:6])[C:3]([OH:5])=[O:4].S(=O)(=O)(O)O.[C:12](O)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[C:12]([O:1][CH:2]([CH3:6])[C:3]([OH:5])=[O:4])(=[O:14])[CH3:13]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 612Lactic AcidHCID 1118Sulfuric Acid

Produkt 1

HCID 790412-Acetoxypropionic AcidAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Reflux a mixture of 2-hydroxy-propionic acid (480 ml, 85% in water) and sulfuric acid (2 mL) in acetic acid (2500 mL) and toluene (300 mL) for overnight. After removal of solvent under vacuum, purify the residue by distillation to give 2-acetoxy-propionic acid (550 g, 92%) as colorless oil. 1H NMR (CDCl3, 400 MHz): δ 9.27 (brs, 1H), 5.10 (m, 1H), 2.13 (s, 3H), 1.53 (d, J=7.2, 3H).

Aufarbeitung

  1. temperatureReflux
  2. customAfter removal of solvent under vacuum
  3. custompurify the residue
  4. distillationby distillation

Quellen und Nachweise

ORD-Eintrag
ord-454818cf5b8a4bdebc359436e7990c79
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648081B2

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