Methanesulfonyl chloride → methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

Reaktionsgleichung

[NH2:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([NH:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3])(=[O:17])=[O:16]

Komponenten

Edukt 2

HCID 31297Methanesulfonyl chloride

HCID 17751895Methyl 4-((1S)-1-aminoethyl)benzoate

Produkt 1

HCID 71262918methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

Versuchsvorschrift

Using methyl (S)-4-(1-aminoethyl)benzoate (0.61 g) and methanesulfonyl chloride (0.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 71, the title compound (0.81 g) was obtained.

Aufarbeitung

customby the reaction and treatment in the same manner
customas in Preparation Example 71

Quellen und Nachweise

ORD-Eintrag: ord-fb924fb53f7e423d92e701fbc088fc69
Quelldatensatz: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08816079B2

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