Sodium Iodide → [4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone

HRID 2411298Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411298
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[I-:24].[Na+]>[Cu]I>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[N:7][C:2]([I:24])=[CH:3][CH:4]=2)=[O:9])[CH2:11][CH2:12]1

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 58484755HCID 58484755, Verbindung

Produkt 1

HCID 86676763[4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanoneAusbeute 62,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)Katalysator

Versuchsvorschrift

Using (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (487 mg) described in Preparation Example 115, sodium iodide (389 mg) and copper(I) iodide (123 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (340.6 mg) was obtained.

Quellen und Nachweise

ORD-Eintrag
ord-e7f19f13b8dd46d7b4335aae1fe0ab00
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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