Methyl p-toluenesulfonate → (S)-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-5-methoxymethylpyrrolidin-2-one
Reaktionsgleichung
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:36])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][OH:30])[CH2:27][CH2:26][C:25]5=[O:31])=[CH:20][C:19]=4[S:32]([CH3:35])(=[O:34])=[O:33])=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.S(C1C=CC(C)=CC=1)(O[CH3:41])(=O)=O>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:36])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][O:30][CH3:41])[CH2:27][CH2:26][C:25]5=[O:31])=[CH:20][C:19]=4[S:32]([CH3:35])(=[O:33])=[O:34])=[O:17])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
Using (S)-1-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-5-hydroxymethylpyrrolidin-2-one (240 mg) described in Example 298 and methyl tosylate (71 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (28 mg) was obtained.