HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Pyrrolidone → 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Pyrrolidone | HCID 12025 | — |
| Edukt | [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone | HCID 58484583 | — |
| Produkt | 1-{5-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-4-methylpyridin-2-yl}pyrrolidin-2-one | HCID 71252162 | — |
Reaktionsschritte
Using pyrrolidin-2-one (326 μL) and [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (400 mg) described in Preparation Example 174 and by the reaction and treatment in the same manner as in Example 323, the title compound (187 mg) was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08816079B2 |
| Quelldatensatz | uspto-grants-2014_08 |
| ORD ID | ord-7773fb8d25254b649fb9c9e9e1be985f |
| Quellennotiz | uspto-grants-2014_08 |