Hydrochloric Acid → HCID 20432562, Verbindung

HRID 2412393

Reaktionsgleichung

Reaktionsgleichung von HRID 2412393
[CH:1]1([C:7]([N:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:22].[H][H]>C(O)C.[Pd]>[ClH:22].[CH:1]1([C:7]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 562738(4-Benzylpiperazin-1-yl)(cyclohexyl)methanoneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 20432562HCID 20432562, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

14.3 g (0.05 mole) of 1-cyclohexanecarbonyl-4-benzylpiperazine dissolved in 250 ml of ethanol and acidified with conc. HCl was treated with hydrogen over a palladium catalyst at 1500 psi and 100° C. The catalyst was removed by filtration and the solvent removed under reduced pressure. The residue was dissolved in isopropanol. On short standing a white crystalline precipitate appeared which was collected by filtration to give 10.0 g of 1-cyclohexanecarbonylpiperazine hydrochloride.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent removed under reduced pressure
  3. dissolutionThe residue was dissolved in isopropanol
  4. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-851606e24c71421794b1a3af844c8fae
Quelldatensatz
uspto-grants-1985_01
Patentnummer
US04492698

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