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Ethanol → HCID 136209487, Verbindung

HRID 2413462
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2413462
Cl.[CH2:2]([O:5][NH2:6])[CH:3]=[CH2:4].[OH-].[Na+].[C:9]([C:14]1[C:15](=[O:30])[CH2:16][CH:17]([C:21]2[C:26]([CH3:27])=[CH:25][C:24]([CH3:28])=[CH:23][C:22]=2[CH3:29])[CH2:18][C:19]=1[OH:20])(=O)[CH2:10][CH2:11][CH3:12].C(O)C>O>[CH2:2]([O:5][N:6]=[C:9]([C:14]1[C:19](=[O:20])[CH2:18][CH:17]([C:21]2[C:22]([CH3:29])=[CH:23][C:24]([CH3:28])=[CH:25][C:26]=2[CH3:27])[CH2:16][C:15]=1[OH:30])[CH2:10][CH2:11][CH3:12])[CH:3]=[CH2:4]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 702Ethanol2×HCID 14798Sodium HydroxideHCID 3084724O-Allylhydroxylamine hydrochlorideHCID 178450313HCID 178450313, Verbindung

Produkt 1

HCID 136209487HCID 136209487, VerbindungAusbeute 76,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962
Water
Lösungsmittel

Versuchsvorschrift

Allyloxyamine hydrochloride (0.72 g) and then a solution of sodium hydroxide (0.25 g) in water (3 ml) were added to a stirred mixture of 2-butyryl-3-hydroxy-5-mesitylcyclohex-2-en-1-one (1.78 g; 5.9 mmole) and 95% ethanol. The progress of the reaction was monitored using thin layer chromatography on silica gel (eluant dichloromethane). On completion of the reaction the ethanol was removed by evaporation using a rotary evaporator and the residue was extracted with dichloromethane. The organic extract was washed with aqueous 5% hydrochloric acid and then with water and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure using a rotary evaporator to give the product, 2-[1-(allyloxyimino)butyl]-3-hydroxy-5-mesitylcyclohex-2-en-1-one (1.6 g) as an oil.

Aufarbeitung

  1. customwas removed by evaporation
  2. customa rotary evaporator
  3. extractionthe residue was extracted with dichloromethane
  4. extractionThe organic extract
  5. washwas washed with aqueous 5% hydrochloric acid
  6. dry with materialwith water and dried over anhydrous magnesium sulfate
  7. customThe solvent was removed by evaporation under reduced pressure
  8. customa rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-a147e6f9e5fe4c67a8fe20d3d01370a6
Quelldatensatz
uspto-grants-1988_01
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04717418

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