L-Tyrosine → Oxitriptan

HRID 2413524

Reaktionsgleichung

Reaktionsgleichung von HRID 2413524
N[C@H](C(O)=O)CC1C=CC([OH:10])=CC=1.[NH2:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[NH:19][CH:18]=1>>[OH:10][C:23]1[CH:24]=[C:25]2[C:20]([NH:19][CH:18]=[C:17]2[CH2:16][C@@H:15]([C:26]([OH:28])=[O:27])[NH2:14])=[CH:21][CH:22]=1

Komponenten

3

Edukt 2

HCID 6057L-TyrosineHCID 6305L-Tryptophan

Produkt 1

HCID 439280Oxitriptan

Versuchsvorschrift

The process is conducted as described in the foregoing Example 6, except that instead of tyrosine 0.21 g of tryptophane is used, the reaction medium pH is 4.0. 0.105 g of 5-hydroxytryptophan is obtained (50% as calculated for the starting compound) having melting point of 287°-288° C. The composition, in percent, is as follows:

Quellen und Nachweise

ORD-Eintrag
ord-64ca46fd4806405892cc4bee130d7e38
Quelldatensatz
uspto-grants-1988_01
Patentnummer
US04718994

Verknüpfte Notizen

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