Ethanol → 2-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone

HRID 2413739

Reaktionsgleichung

Reaktionsgleichung von HRID 2413739
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10](=[S:13])[NH:11][NH2:12])[CH2:3][CH2:2]1.[C:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)(=O)[CH3:15].C(O)C>C(O)(=O)C>[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][NH:9][C:10](=[S:13])[NH:11][N:12]=[C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[CH3:15])[CH2:5][CH2:6]1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 142862-AcetylpyridineHCID 7362093-Amino-1-(2-(morpholin-4-yl)ethyl)thiourea

Produkt 1

HCID 544028592-Acetylpyridine 4-(2-morpholinoethyl)thiosemicarbazone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 6.00 g (0.0294 mole) of 4-(2-morpholinoethyl)thiosemicarbazide, 3.91 g (0.0323 mole) of 2-acetylpyridine, 20 mL of 95% ethanol, and 0.4 mL of glacial acetic acid was heated under reflux for 1.25 hours. The mixture then stood overnight at room temperature. Colourless crystals were collected and recrystallised from 40 mL of 95% ethanol; yield 7.81 g (86%) of pale yellow crystals of 2-acetylpyridine 4-(2-morpholinoethyl)thioseicarbazone, mp 167.5°-169° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 1.25 hours
  3. customColourless crystals were collected
  4. customrecrystallised from 40 mL of 95% ethanol

Quellen und Nachweise

ORD-Eintrag
ord-a7071a5459f34bbc99fc2494dadebae9
Quelldatensatz
uspto-grants-1988_01
Patentnummer
US04719221

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