2,3-Diaminopyridine → HCID 66869810, Verbindung

HRID 241412

Reaktionsgleichung

Reaktionsgleichung von HRID 241412
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4](O)=O.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([NH2:18])[C:13]=1[NH2:19].[OH-].[Na+]>O>[Br:11][C:8]1[CH:7]=[C:3]([C:4]2[NH:18][C:14]3[C:13]([N:19]=2)=[N:12][CH:17]=[CH:16][CH:15]=3)[C:2]([NH2:1])=[N:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 99562,3-DiaminopyridineHCID 14798Sodium HydroxideHCID 7374452-Amino-5-bromonicotinic acid

Produkt 1

HCID 66869810HCID 66869810, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

50 mg (0.230 mmol) I) of 2-amino-5-bromonicotinic acid and 27.6 mg (0.253 mmol) of pyridine-2,3-diamine are added to 451.5 mg (5 mmol) of polyphosphoric acid, and the mixture is stirred at 160° C. for 4 days. The reaction mixture is cooled to room temperature, water is added, and the mixture is adjusted to pH 12 by means of 1N NaOH. The precipitate formed is filtered off with suction and dried, giving 5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled to room temperature
  2. customThe precipitate formed
  3. filtrationis filtered off with suction
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-725e8d02c86f429892222bd9e70741e6
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648201B2

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