Water → 1-(4-Bromovaleroyl)-4-methylpiperidine

HRID 2414781Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2414781
[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12](Cl)=[O:13].O>C(#N)C>[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12]([N:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]1)=[O:13]

Komponenten

5

Edukt 3

HCID 962WaterHCID 693814-MethylpiperidineHCID 22643413HCID 22643413, Verbindung

Produkt 1

HCID 226434181-(4-Bromovaleroyl)-4-methylpiperidineAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

1.09 g of 4-methylpiperidine was dissolved in 10 ml of acetonitrile and added dropwise with 1.09 g of 4-bromovaleroyl chloride. The reaction mixture was stirred for 2 hours, then poured into water and extracted with ethyl acetate. The organic layer was washed with wafer and dried over sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.07 g of the title compound (yield: 82%).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with wafer
  3. dry with materialdried over sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-be3d31fd80a34a63842c8ba79f41da24
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06815455B1

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