Hydrochloric Acid → HCID 22640723, Verbindung

HRID 2415134Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2415134
[C:1](/[C:3](=[CH:7]\[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)/[C:4]([NH2:6])=[O:5])#[N:2].Cl>C(O)C.[Pd]>[NH2:2][CH2:1][CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([NH2:6])=[O:5]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 725466BENZALCYANOACETAMIDE

Produkt 1

HCID 22640723HCID 22640723, VerbindungAusbeute 119,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of (E)-2cyano-3-phenyl-acrylamide (0.50 g, 2.91 mmol) was dissolved in ethanol (25 mL). Concentrated HCl (1 mL) was added, followed by 10% degussa palladium on carbon (1.0 g). The mixture was subjected to hydrogenation conditions (55 psi) for 24 hours. It was filtered through Celite and concentrated to give the product (0.62 g, 100%) as a white solid. [M+H]+ 179.

Aufarbeitung

  1. filtrationIt was filtered through Celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-291a905c7d0841f0a7594e8035bd4e58
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06818655B2

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