Bromine → 2-Bromo-1-(2,3-dihydro-1-benzofuran-5-yl)ethan-1-one

HRID 2415291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2415291
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](=[O:12])[CH3:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[Br:13]Br>O1CCOCC1>[Br:13][CH2:11][C:10]([C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=1)=[O:12]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 1452201-(2,3-Dihydro-5-benzofuranyl)ethanone

Produkt 1

HCID 101057272-Bromo-1-(2,3-dihydro-1-benzofuran-5-yl)ethan-1-oneAusbeute 38 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 1-(2,3-dihydro-benzofuran-5-yl)-ethanone (2.5 g, 15.4 mmol) (Lancaster) in dioxane (2 mL) was added dropwise a solution of bromine (2.96 g, 18.5 mmol) in dioxane (60 mL). After stirring 15 minute the mixture was concentrated in vacuo and the residue was purified by chromatography on silica gel (2:1 hexane-dichloromethane) to provide 1.41 g (38%) of 2-bromo-1-(2,3-dihydro-benzofuran-5-yl)-ethanone.

Aufarbeitung

  1. concentrationwas concentrated in vacuo
  2. customthe residue was purified by chromatography on silica gel (2:1 hexane-dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-faa55760b9ec4d199dae37b0ad06697a
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06818663B2

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