Water → 6-[(3-Fluorophenyl)methoxy]-1,2,3,4-tetrahydroisoquinoline

HRID 2415448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2415448
[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13](=O)[NH:12][CH2:11][CH2:10]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH2:13][NH:12][CH2:11][CH2:10]2

Komponenten

5

Edukt 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 226419086-[(3-Fluorophenyl)methoxy]-3,4-dihydroisoquinolin-1(2H)-one

Produkt 1

HCID 226418956-[(3-Fluorophenyl)methoxy]-1,2,3,4-tetrahydroisoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 6-(3-fluoro-benzyloxy)-3,4-dihydro-2H-isoquinolin-1-one (1.2 g, 4.423 mmol) and lithium aluminum hydride (0.337 g, 8,84 mmol) in tetrahydrofuran (24 ml) was heated to 60° C. for 8 h. Water was added and an 15% aqueous solution of sodium hydroxide and the mixture was extracted with ethylacetate. After drying of the organic layer with MgSO4, filtration and evaporation, an oil was obtained (1.14 g, 99%). MS: m/e 258.0 (M+H+).

Aufarbeitung

  1. extractionan 15% aqueous solution of sodium hydroxide and the mixture was extracted with ethylacetate
  2. dry with materialAfter drying of the organic layer with MgSO4, filtration and evaporation
  3. customan oil was obtained (1.14 g, 99%)

Quellen und Nachweise

ORD-Eintrag
ord-d1b0945d0dd242d1a66d63c50ca1cd32
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06818774B2

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