2-Oxoglutaric Acid → HCID 178514459, Verbindung

HRID 2415679

Reaktionsgleichung

Reaktionsgleichung von HRID 2415679
Cl.[NH:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)[NH2:3].[O:14]=[C:15]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:16](O)=[O:17]>O>[O:14]=[C:15]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:16](=[N:2][NH2:3])[OH:17].[NH:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)[NH2:3]

Komponenten

4

Edukt 2

HCID 512-Oxoglutaric AcidHCID 9351Hydralazine Hydrochloride

Produkt 1

HCID 178514459HCID 178514459, VerbindungAusbeute 159,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1-hydrazinophthalazine hydrochloride (395 mg; 2 mmol) is dissolved in 5 ml of water. To this an aqueous solution of α-ketoglutaric acid (1 g; 7 mmol) is added and the reaction mixture is allowed to stand overnight at room temperature. The solid precipitate is filtered off and dried in vacuo to yield 510 mg of 1-hydrazinophthalazine α-ketoglutarate hydrazone (88% theoretical yield). [British Journal of Clinical Pharmacology 5: 489-494 (1978)].

Aufarbeitung

  1. filtrationThe solid precipitate is filtered off
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d6b737a220e744ce8667c0bda386b983
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06821974B2

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