Ammonia → 8-Bromo-2-chloroquinoline

HRID 2415891

Reaktionsgleichung

Reaktionsgleichung von HRID 2415891
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[NH:10][C:9](=O)[CH:8]=[CH:7]2.O.N.P(Cl)(Cl)([Cl:17])=O>>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([Cl:17])[CH:8]=[CH:7]2

Komponenten

5

Edukt 4

HCID 222AmmoniaHCID 962WaterHCID 24813Phosphorus oxychlorideHCID 109330948-Bromo-1,2-dihydroquinolin-2-one

Produkt 1

HCID 109557558-Bromo-2-chloroquinoline

Versuchsvorschrift

A suspension of 2.8 g (12.49 mmol) of 8-bromo-1H-quinoline-2-one in 20 ml of phosphorus oxychloride is refluxed for 90 minutes and the reaction mixture is cooled and then added dropwise to 200 ml of water. The aqueous solution is made basic with concentrated ammonia solution, the precipitate formed is filtered off and washed with water.

Aufarbeitung

  1. temperatureis refluxed for 90 minutes
  2. temperaturethe reaction mixture is cooled
  3. customthe precipitate formed
  4. filtrationis filtered off
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-5a0e0f02466448bca837c883e86815a5
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06821967B2

Verknüpfte Notizen

Wird geladen…