Sodium borohydride → 3-(4-(2-Pyrazinyl)phenyl)prop-2-en-1-ol

HRID 2416565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2416565
[BH4-].[Na+].[N:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH:17]=[O:18])=[CH:11][CH:10]=2)[CH:4]=1>C(O)C>[N:6]1[CH:7]=[CH:8][N:3]=[CH:4][C:5]=1[C:9]1[CH:10]=[CH:11][C:12]([CH:15]=[CH:16][CH2:17][OH:18])=[CH:13][CH:14]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 22631067(2E)-3-[4-(3-pyrazinyl)phenyl]-2-propenal

Produkt 1

HCID 697135193-(4-(2-Pyrazinyl)phenyl)prop-2-en-1-olAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium borohydride (90 mg, 2.38 mmol) was added to a suspension of (2E)-3-[4-(3-pyrazinyl)phenyl]-2-propenal (400 mg, 1.90 mmol, prepared as described in Reference Example 18) in ethanol (5 mL) maintained in a room temperature water bath. After 20 min, the reaction was quenched with water (10 mL), allowed to stir for 10 min, and then concentrated to remove the ethanol. The solids were removed by filtration, washed with water, and dried in vacuo to provide 360 mg (89%) of the title compound. MS 213 (M+H)+.

Aufarbeitung

  1. customthe reaction was quenched with water (10 mL)
  2. concentrationconcentrated
  3. customto remove the ethanol
  4. customThe solids were removed by filtration
  5. washwashed with water
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-25886b0cbfaa43a78a47da7d28b3a119
Quelldatensatz
uspto-grants-2004_11
Patentnummer
US06825172B2

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