Dimethylformamide → 5-[(morpholin-4-yl)methyl]-1H-pyrrole-2-carbaldehyde
Reaktionsgleichung
CN([CH:4]=[O:5])C.O=P(Cl)(Cl)Cl.[NH:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][N:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1.C([O-])(=O)C.[K+].[OH-].[Na+]>C(Cl)Cl>[N:17]1([CH2:16][C:12]2[NH:11][C:15]([CH:4]=[O:5])=[CH:14][CH:13]=2)[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1Komponenten
Edukt 5
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
To a solution of DMF (18.04 mmoles) in DCM (10 ml) there is added POCl3, dropwise, at 0° C. After stirring for 5 minutes, a solution of the compound obtained in Step A (9.02 mmoles) is added dropwise. After stiffing for 3 hours at 0° C., the reaction mixture is heated at 40° C. for 30 minutes. At ambient temperature, an aqueous solution of potassium acetate (32 mmoles) is added and then the reaction mixture is stirred at 40° C. for 30 minutes. At ambient temperature, the solution is brought to alkaline pH using 2M NaOH solution and is then extracted with DCM. The organic phase is washed with water and with saturated NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness. The residue obtained is purified on silica gel (SiO2; gradient DCM/AcOEt) to yield the title product.
Aufarbeitung
- customat 0° C
- waitAfter stiffing for 3 hours at 0° C.
- stirringthe reaction mixture is stirred at 40° C. for 30 minutes
- customAt ambient temperature
- extractionis then extracted with DCM
- washThe organic phase is washed with water and with saturated NaCl solution
- dry with materialdried over sodium sulphate
- filtrationfiltered
- customevaporated to dryness
- customThe residue obtained
- customis purified on silica gel (SiO2; gradient DCM/AcOEt)
Quellen und Nachweise
- ORD-Eintrag
- ord-3ceaa16af83f475a96ac75a707c92cbe
- Quelldatensatz
- uspto-grants-2014_02
- Patentnummer
- US08653073B2
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