{4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrol-2-yl}methanol → 4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

HRID 241719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 241719
[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH2:13][OH:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>C1COCC1.O=[Mn]=O>[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH:13]=[O:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 1

HCID 66636497{4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrol-2-yl}methanol

Produkt 1

HCID 866508254-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of the product obtained in Step I (0.09 g) in THF (3.8 ml) there is added activated MnO2 (0.315 g). After stirring for 20 hours at ambient temperature, the mixture is filtered and the filtrate is evaporated to dryness to yield the title product, which is used directly in the next step.

Aufarbeitung

  1. filtrationthe mixture is filtered
  2. customthe filtrate is evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a488fc4daaf24ca5b0d43db27dfd412e
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653073B2

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