Ammonium Hydroxide → HCID 13338422, Verbindung

HRID 2417663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2417663
Cl[C:2]1[C:3]2[N:11]([CH3:12])[N:10]=[C:9]([CH3:13])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[NH2:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17].[OH-].[NH4+]>C1(C)C=CC=CC=1>[CH3:12][N:11]1[C:3]2[C:2]([NH:14][CH:15]([CH2:18][CH3:19])[CH2:16][OH:17])=[N:7][C:6]([CH3:8])=[N:5][C:4]=2[C:9]([CH3:13])=[N:10]1

Komponenten

5

Edukt 3

HCID 14923Ammonium HydroxideHCID 221292-Amino-1-butanolHCID 133384077-Chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine

Produkt 1

HCID 13338422HCID 13338422, VerbindungAusbeute 30,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 8 g (0.04 mol) of 7-chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine (Ex. 3) and 9 g (0.1 mol) of 2-amino-1-butanol in 75 ml of toluene is heated on the steam bath four hours. The warm solution is shaken with 100 ml of 4N ammonium hydroxide. The aqueous extract is concentrated in vacuo to give 3 g of 2-[1,3,5-trimethyl-1-H-pyrazolo[4,3-d]pyrimidin-7-yl]amino-1-butanol, mp 165°-168° C. Another 2.2 g of product is obtained by concentrating the toluene solution.

Aufarbeitung

  1. temperatureis heated on the steam bath four hours
  2. extractionThe aqueous extract
  3. concentrationis concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-57062a4cfad54e8f8747450cc0ca1c5c
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04469868

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