Hydrochloric Acid → 4-Amino-1-ethyl-3-methyl-1H-pyrazole-5-carboxamide

HRID 2417678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2417678
[CH2:1]([N:3]1[C:7]([C:8]([NH2:10])=[O:9])=[C:6]([N+:11]([O-])=O)[C:5]([CH3:14])=[N:4]1)[CH3:2].Cl>C(O)C.O.[Fe]>[NH2:11][C:6]1[C:5]([CH3:14])=[N:4][N:3]([CH2:1][CH3:2])[C:7]=1[C:8]([NH2:10])=[O:9]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 12148391H-Pyrazole-5-carboxamide, 1-ethyl-3-methyl-4-nitro-

Produkt 1

HCID 138229264-Amino-1-ethyl-3-methyl-1H-pyrazole-5-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23925IronKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 20 g (0.1 mol) of the above amide in 150 ml of ethanol and 30 ml of water containing 3 ml of conc. HCl is stirred under reflux with 25 g of iron powder for three hours and filtered warm using filter-cell. The filtrate is evaporated in vacuo to yield a pink solid, mp 143°-145° C. (from ethyl acetate-pet. ether) of 4-amino-1-ethyl-3-methylpyrazole-5-carboxamide. The reaction of this aminopyrazole with 18 ml acetic anhydride in 250 ml of methylene dichloride gives 18.5 g of N-(1-ethyl-5-carboxamido 3-methylpyrazol-4-yl)acetamide, mp 248°-250° C.

Aufarbeitung

  1. filtrationfiltered
  2. temperaturewarm
  3. filtrationusing filter-cell
  4. customThe filtrate is evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ce23fb62d0284d3385dce65af4dce8ac
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04469868

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