3-Amino-1-propanol → 1-(2-Chloro-5-nitrophenyl)-3-(3-hydroxypropyl)thiourea

HRID 2417910

Reaktionsgleichung

Reaktionsgleichung von HRID 2417910
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N:11]=[C:12]=[S:13].[NH2:14][CH2:15][CH2:16][CH2:17][OH:18]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][OH:18])=[S:13]

Komponenten

4

Edukt 2

HCID 90863-Amino-1-propanolHCID 926811-Chloro-2-isothiocyanato-4-nitrobenzene

Produkt 1

HCID 30187341-(2-Chloro-5-nitrophenyl)-3-(3-hydroxypropyl)thioureaAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 24 parts of 1-chloro-2-isothiocyanato-4-nitrobenzene in 200 parts of ethanol 95% are added dropwise 9 parts of 3-amino-1-propanol at a temperature below 20° C. Upon completion, stirring is continued for 30 minutes at room temperature. The reaction mixture is evaporated. The residue is crystallized from acetonitrile. The product is filtered off and dried, yielding 23 parts (72%) of N-(2-chloro-5-nitrophenyl)-N'-(3-hydroxypropyl)thiourea; mp. 126.8° C.

Aufarbeitung

  1. customThe reaction mixture is evaporated
  2. customThe residue is crystallized from acetonitrile
  3. filtrationThe product is filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b508b8a7443b4001aa8c6558af803e13
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04471117

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