Hydrogen Bromide → 4-(3-Bromopropyl)phenol

HRID 2417990Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2417990
[BrH:1].O[CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1>O>[Br:1][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 824523-(4-Hydroxyphenyl)propanol

Produkt 1

HCID 148170364-(3-Bromopropyl)phenolAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 48% hydrobromic acid solution (110 g) was added 4-(3-hydroxypropyl)phenol (25 g) and heated on a steam bath for 3 hours. After cooling, water (500 ml) was added, the oil was extracted with ether, washed with water and then with dilute sodium bicarbonate solution. The etheral extract was dried over potassium carbonate, evaporated and the residue was distilled in a Kugelrohr apparatus giving 29.6 g (84%) of 4-(3-bromopropyl)phenol, bp 180° (2 mm). The product was 92.6% pure by gas chromatography and mass spectrum was compatible with 4-(3-bromopropyl)phenol.

Aufarbeitung

  1. temperatureheated on a steam bath for 3 hours
  2. temperatureAfter cooling
  3. extractionthe oil was extracted with ether
  4. washwashed with water
  5. extractionThe etheral extract
  6. dry with materialwas dried over potassium carbonate
  7. customevaporated
  8. distillationthe residue was distilled in a Kugelrohr apparatus

Quellen und Nachweise

ORD-Eintrag
ord-7a4a9b68a7b04eec8c287a132d269c07
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04471116

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