Cysteamine Hydrochloride → HCID 15592296, Verbindung
Reaktionsgleichung
Cl.[NH2:2][CH2:3][CH2:4][SH:5].Cl.[CH3:7][N:8]([CH3:16])[C:9]1[S:10][CH:11]=[C:12]([CH2:14]Cl)[N:13]=1>Cl>[CH3:7][N:8]([CH3:16])[C:9]1[S:10][CH:11]=[C:12]([CH2:14][S:5][CH2:4][CH2:3][NH2:2])[N:13]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Cysteamine hydrochloride (5.24 g; 45.9 mmoles) and 2-dimethylamino-4-chloromethylthiazole hydrochloride (9.8 g; 45.9 mmoles) [prepared from N,N-dimethylthiourea and 1,3-dichloro-2-propanone] were dissolved in 45 ml of concentrated hydrochloric acid and heated at an oil bath temperature of 100° for 96 hours. The mixture was evaporated under reduced pressure and the residue made basic with 40% aqueous NaOH. The aqueous phase was extracted with methyl acetate, dried and evaporated to give the title compound as an oil which was used without further purification in Step B.