Acetic Anhydride → HCID 13577653, Verbindung

HRID 2418239Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2418239
[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH3:13])[NH:7]2.[OH-].[Na+].[C:16](OC(=O)C)(=[O:18])[CH3:17]>S(=O)(=O)(O)O>[C:16]([N:7]1[C:8]2[C:3](=[C:2]([Br:1])[C:11]([F:12])=[CH:10][CH:9]=2)[CH2:4][CH2:5][CH:6]1[CH3:13])(=[O:18])[CH3:17]

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 128968175-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

Produkt 1

HCID 13577653HCID 13577653, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidKatalysator

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To 6.0 g of 5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine was added 50 ml of acetic anhydride and one drop of concentrated sulfuric acid. The solution was heated on a steam bath for two hours, then cooled to about 20° C. The solution was basified with 10% sodium hydroxide solution. The solution was extracted with chloroform, and the chloroform extracts were evaporated to provide an oil which was distilled in vacuo to provide N-acetyl-5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine. The structural assignment was supported by nuclear magnetic resonance spectral analysis.

Aufarbeitung

  1. temperatureThe solution was heated on a steam bath for two hours
  2. extractionThe solution was extracted with chloroform
  3. customthe chloroform extracts were evaporated
  4. customto provide an oil which
  5. distillationwas distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e7494964c2a0408bb219209964f9baf6
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04472407

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