Hydrochloric Acid → 2-Sulfamoyl-1,3-benzothiazol-6-yl dimethylcarbamate

HRID 2418290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2418290
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]=[C:7]([S:9]([NH2:12])(=[O:11])=[O:10])[S:8][C:4]=2[CH:3]=1.[CH3:15][N:16]([CH3:20])[C:17](Cl)=[O:18].Cl>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[CH3:15][N:16]([CH3:20])[C:17](=[O:18])[O:1][C:2]1[CH:14]=[CH:13][C:5]2[N:6]=[C:7]([S:9](=[O:11])(=[O:10])[NH2:12])[S:8][C:4]=2[CH:3]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 6598Dimethylcarbamoyl Chloride2×HCID 68521296-Hydroxy-1,3-benzothiazole-2-sulfonamide

Produkt 1

HCID 444619572-Sulfamoyl-1,3-benzothiazol-6-yl dimethylcarbamateAusbeute 76.325,203 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a stirred solution of 6-hydroxy-2-benzothiazolesulfonamide (2.3 g, 0.01 mole) and 4-dimethylaminopyridine (200 mg) in pyridine (25 ml) was added dimethylcarbamoyl chloride (0.95 ml, 0.01 mmole). After stirring for 18 hours additional dimethylcarbamoyl chloride (1.5 ml) was added and stirring was continued for 18 hours. The reaction mixture was poured into ice water and excess hydrochloric acid to give 2.3 g of (2-sulfamoyl-6-benzothiazolyl) N,N-dimethylcarbamate which melts at 208°-209° C. after recrystallization from 2-propanol.

Aufarbeitung

  1. additionwas added

Quellen und Nachweise

ORD-Eintrag
ord-33a5ebb4954e46929f019ad73b6f61d9
Quelldatensatz
uspto-grants-1984_09
Patentnummer
US04472417

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