4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-morpholinoethanone

HRID 2421394Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2421394
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)=[O:10]>C1(C)C=CC=CC=1>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[CH2:8][N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 74544-Bromophenacyl bromideHCID 8083Morpholine

Produkt 1

HCID 4108821-(4-Bromophenyl)-2-morpholinoethanoneAusbeute 101,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

Morpholine (4.35 g) in dry toluene (8 ml) was stirred during the addition of aliquots of 2-bromo-1-(4-bromophenyl)ethanone (6.95 g) in dry toluene (70 ml). The resulting precipitate was removed by filtration and the filtrate evaporated to give the product (J. Amer. Chem. Soc., 1940, 62, 2882) as a pale yellow solid (7.2 g).

Aufarbeitung

  1. customThe resulting precipitate was removed by filtration
  2. customthe filtrate evaporated

Quellen und Nachweise

ORD-Eintrag
ord-b40b4806bb32466aa8de9b505667e52b
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07956084B2

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