Methyl [4-methyl-2-(4-nitrobenzyl)-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate → Methyl[2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate

HRID 2422163

Reaktionsgleichung

Reaktionsgleichung von HRID 2422163
[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[C:6]([CH3:26])=[N:7][C:8]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=2)=[N:9][C:10]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1COCC1.[Pd]>[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[C:6]([CH3:26])=[N:7][C:8]([CH2:16][C:17]2[CH:18]=[CH:19][C:20]([NH2:23])=[CH:21][CH:22]=2)=[N:9][C:10]=1[N:11]1[CH2:12][CH2:13][CH2:14][CH2:15]1

Komponenten

4

Edukt 1

HCID 59514538Methyl [4-methyl-2-(4-nitrobenzyl)-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate

Produkt 1

HCID 59514524Methyl[2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of methyl[4-methyl-2-(4-nitrobenzyl)-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate (0.074 g, 0.20 mmol) in anhydrous THF (2 mL) was added Pd/C (10% Pd, 0.050 g) and the resulting black suspension was stirred under an atmosphere of hydrogen. After 1 hour; the reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to give methyl[2-(4-aminobenzyl)-4-methyl-6-pyrrolidin-1-ylpyrimidin-5-yl]acetate.

Aufarbeitung

  1. filtrationthe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-78d3a577c92d4ec38bb37179ec2c4ec4
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960393B2

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