Water → HCID 67146541, Verbindung

To an ice-cooled solution of N-methyl-4-phenyl-2-thiazolamine (0.30 g, 1.7 mmol) in N,N-dimethylformamide (5 mL) was added 60% sodium hydride (72 mg, 1.8 mmol), and the mixture was stirred for 30 min. Ethyl 4-[(3-bromopropyl)oxy]benzenepropanoate (0.57 g, 1.8 mmol), was added, and the mixture was stirred at room temperature for 3 hrs. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=15:1) to give the title compound (0.58 g, yield 80%). oil.

1. stirringthe mixture was stirred at room temperature for 3 hrs
2. extractionthe mixture was extracted with ethyl acetate
3. washThe extract was washed with water
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=15:1)

ORD-Eintrag

ord-1c66238220094869a199f0da31a991e4

Quelldatensatz

uspto-grants-2011_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07960369B2