Hydrazine hydrate (1:1) → (6-Morpholin-4-ylpyrimidin-4-yl)hydrazine

HRID 242247

Reaktionsgleichung

Reaktionsgleichung von HRID 242247
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:3]=1.O.[NH2:15][NH2:16]>C(O)C>[NH:15]([C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:3]=1)[NH2:16]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 7960704-(6-Chloropyrimidin-4-yl)morpholine

Produkt 1

HCID 13393622(6-Morpholin-4-ylpyrimidin-4-yl)hydrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

53.0 g (2.7 mmol) 4-(6-chloropyrimidin-4-yl)morpholine are initially introduced into 260 ml ethanol. 132.9 g (2.7 mol) hydrazine hydrate are added and the mixture is stirred under reflux for 16 h. Thereafter, it is cooled to RT and approx. half of the solvent is removed by distillation. The mixture is cooled to 0° C. and the solid formed is filtered off It is rinsed with cold ethanol and the solid is dried first in air and then in vacuo.

Aufarbeitung

  1. temperatureunder reflux for 16 h
  2. customis removed by distillation
  3. temperatureThe mixture is cooled to 0° C.
  4. customthe solid formed
  5. filtrationis filtered off It
  6. washis rinsed with cold ethanol
  7. customthe solid is dried first in air

Quellen und Nachweise

ORD-Eintrag
ord-b52930eea51e4977b80f10005dc45379
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653111B2

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