Ethyl 2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetate → Ethyl 2-(4-(5-aminoquinolin-6-yloxy)-3-methoxyphenyl)acetate

HRID 2423318

Reaktionsgleichung

Reaktionsgleichung von HRID 2423318
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:11]([N+:20]([O-])=O)=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]=[CH:15][CH:14]=[CH:13]2>CCO.[Pd]>[NH2:20][C:11]1[C:10]([O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:4][C:3]=2[O:2][CH3:1])=[CH:19][CH:18]=[C:17]2[C:12]=1[CH:13]=[CH:14][CH:15]=[N:16]2

Komponenten

4

Edukt 1

HCID 59864865Ethyl 2-(3-methoxy-4-(5-nitroquinolin-6-yloxy)phenyl)acetate

Produkt 1

HCID 59864773Ethyl 2-(4-(5-aminoquinolin-6-yloxy)-3-methoxyphenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Pd/C (30 mg) was added to 24.3 (310 mg) in EtOH (10 mL). The mixture was stirred under hydrogen at room temperature for 6 h. The catalyst was removed by filtration through celite. The filtrate was concentrated under vacuum to give 24.4. MS ESI (pos.) m/z: 353.1 (M+H).

Aufarbeitung

  1. customThe catalyst was removed by filtration through celite
  2. concentrationThe filtrate was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c8724ae8dfef40108eebf9c767ea9de2
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07960567B2

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