L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- → HCID 71105111, Verbindung

HRID 242387

Reaktionsgleichung

Reaktionsgleichung von HRID 242387
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([C:16](=[O:18])[CH3:17])[N:6]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[CH:7]=1.[NH:19]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C@H:20]([C:25]([OH:27])=O)[CH2:21][CH:22]([CH3:24])[CH3:23].CCN=C=N[CH2:40][CH2:41][CH2:42]N(C)C.Cl>ClCCl.CN(C1C=CN=CC=1)C>[C:16]([C:5]1[N:6]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:14])([CH3:13])[CH3:15])[CH:7]=[C:3]([CH2:2][O:1][C:25](=[O:27])[C@@H:20]([NH:19][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:21][C:22]2[CH:23]=[CH:42][CH:41]=[CH:40][CH:24]=2)[N:4]=1)(=[O:18])[CH3:17]

Komponenten

6

Edukt 3

HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 710869721-(4-hydroxymethyl-1-(2-trimethylsilylethoxymethyl)-1H-imidazol-2-yl)ethanone

Produkt 1

HCID 71105111HCID 71105111, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The compound (2.00 g) obtained in (3) was dissolved in dichloromethane (10 mL), and Boc-Leu-OH (2.21 g), EDC.HCl (2.13 g), and DMAP (0.99 g) were added while stirring. After the stirring was continued for 1 day, the solvent was distilled off under reduced pressure. The resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%) using silica gel column (product name: Hi-Flash Column 3 L, manufactured by Yamazen Corporation) to afford the title compound (3.20 g).

Aufarbeitung

  1. distillationthe solvent was distilled off under reduced pressure
  2. customThe resulting residue was purified by flash chromatography (ethyl acetate/chloroform=0%→25%)

Quellen und Nachweise

ORD-Eintrag
ord-ee60c6e8bc1744969018dda8e777ca7c
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653126B2

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