HCID 67245096, Verbindung → 1-(Aminomethyl)-3-methylcyclohexanol

HRID 2424830Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2424830
C([NH:8][CH2:9][C@:10]1([OH:17])[CH2:15][CH2:14][CH2:13][C@H:12]([CH3:16])[CH2:11]1)C1C=CC=CC=1>[Pd].CO>[NH2:8][CH2:9][C:10]1([OH:17])[CH2:15][CH2:14][CH2:13][CH:12]([CH3:16])[CH2:11]1

Komponenten

4

Edukt 1

HCID 67245096HCID 67245096, Verbindung

Produkt 1

HCID 434366501-(Aminomethyl)-3-methylcyclohexanolAusbeute 90,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of (1S,3S)-1-[(benzylamino)methyl]-3-methylcyclohexanol (4.5 g) and 5% palladium on carbon (500 mg) in methanol (40 ml) was stirred under a hydrogen atmosphere of 4 bar for 72 hours. The reaction was filtered through celite, washed with methanol (2×) and concentrated in vacuo to afford 1S,3S)-1-(Aminomethyl)-3-methylcyclohexanol as a colourless oil (2.5 g).

Aufarbeitung

  1. filtrationThe reaction was filtered through celite
  2. washwashed with methanol (2×)
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-45e7d412ba124be7824c71bf0e58575c
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964616B2

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