Bromine → HCID 67246500, Verbindung

HRID 2425316Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2425316
[CH2:1]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[C:14](=[O:18])[CH2:13][CH2:12]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:13]1[CH2:12][C:11]2[C:15](=[CH:16][CH:17]=[C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:10]=2)[C:14]1=[O:18]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 67248522HCID 67248522, Verbindung

Produkt 1

HCID 67246500HCID 67246500, VerbindungAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 2 (1.094 g, 4.48 mmol) in CHCl3 (10 mL) at 40° C. was added Br2 (0.23 mL, 4.477 mmol) dropwise over 15 minutes. The reaction was left to stir for 30 minutes. The resulting solution was concentrated and purified with silica gel chromatography eluding with hexanes-EtOAc (9:1). The reaction provided 3 (1.212 g, 3.75 mmol, 84%) as an orange liquid.

Aufarbeitung

  1. waitThe reaction was left
  2. concentrationThe resulting solution was concentrated
  3. custompurified with silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-36f6bae739ec4cc2847bb8c17991aae6
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964649B2

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