(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 67244329, Verbindung

HRID 2425434

Reaktionsgleichung

Reaktionsgleichung von HRID 2425434
[Cl:1][C:2]1[C:11]2[C:10]([S:12](Cl)(=[O:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[H][H].[C:18]([O:22][C:23]([NH:25][CH:26]([CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[CH3:27])=[O:24])([CH3:21])([CH3:20])[CH3:19].BrC1C2C(S(Cl)(=O)=O)=CC=CC=2C=NC=1.C(OC(N[C@H]1CCNC1)=O)(C)(C)C>>[C:18]([O:22][C:23]([NH:25][CH:26]([CH:28]1[CH2:29][CH2:30][N:31]([S:12]([C:10]2[C:11]3[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=3[CH:7]=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH2:32][CH2:33]1)[CH3:27])=[O:24])([CH3:19])([CH3:20])[CH3:21]

Komponenten

6

Edukt 5

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 145800584-Bromo-5-isoquinolinesulfonyl chlorideHCID 221219084-Chloroisoquinoline-5-sulfonyl chlorideHCID 43523185tert-butyl N-[1-(piperidin-4-yl)ethyl]carbamateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 67244329HCID 67244329, Verbindung

Versuchsvorschrift

4-Chloro-5-isoquinolinesulfonyl chloride obtained in Reference Example 7 (131 mg) and 4-[1-(tert-butoxycarbonylamino)ethyl]piperidine (134 mg) prepared according to the method described in WO05/080394 were used in the method of Example 1-1, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-(tert-butoxycarbonylamino)pyrrolidine, respectively, to obtain the title compound (211 mg).

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-24ed6022fcfb4fcb841b35275abe4f07
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964613B2

Verknüpfte Notizen

Wird geladen…