Formaldehyde → N-(methoxymethyl)-N-((trimethylsilyl)methyl)prop-2-en-1-amine

HRID 2425527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2425527
[CH3:1][Si:2]([CH2:5][NH:6][CH2:7][CH:8]=[CH2:9])([CH3:4])[CH3:3].[CH2:10]=O.CO.[C:14]([O-:17])([O-])=O.[K+].[K+]>COC(C)(C)C.O>[CH3:10][O:17][CH2:14][N:6]([CH2:5][Si:2]([CH3:4])([CH3:3])[CH3:1])[CH2:7][CH:8]=[CH2:9]

Komponenten

7

Edukt 4

HCID 712FormaldehydeHCID 887MethanolHCID 11430Potassium CarbonateHCID 12489587N-((trimethylsilyl)methyl)prop-2-en-1-amine

Produkt 1

HCID 18374742N-(methoxymethyl)-N-((trimethylsilyl)methyl)prop-2-en-1-amineAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 15413tert-Butyl methyl etherLösungsmittel

Versuchsvorschrift

To N-((trimethylsilyl)methyl)prop-2-en-1-amine (21 g, 146.5 mmol) was slowly added aqueous formaldehyde (20 g; 37% w/w) while stirring at room temperature. After 5 minutes additional stirring methanol (8 g) was added followed by the addition of K2CO3 (24 g). The reaction mixture was stirred overnight at room temperature. Water (100 ml) was added, followed by addition of tert-butyl methyl ether (75 ml). The organic layer was separated. The aqueous layer was extracted with tert-butyl methyl ether (75 ml). The combined organic extracts were dried with Na2SO4. Concentration under vacuum gave N-(methoxymethyl)-N-((trimethylsilyl)methyl)prop-2-en-1-amine as a clear oil (24 g, 128.1 mmol) in 87% c.y.

Aufarbeitung

  1. additionwas added
  2. stirringThe reaction mixture was stirred overnight at room temperature
  3. customThe organic layer was separated
  4. extractionThe aqueous layer was extracted with tert-butyl methyl ether (75 ml)
  5. dry with materialThe combined organic extracts were dried with Na2SO4
  6. concentrationConcentration under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2737a701769245c38e20c84ef9225fa2
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07964739B2

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