Ammonium Hydroxide → 1-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamide

HRID 242573Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 242573
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:24].[NH4+]>S(=O)(=O)(O)O>[CH2:1]([N:8]1[CH2:9][CH2:10][C:11]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)([C:14]([NH2:15])=[O:24])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 704181-Benzyl-4-((4-chlorophenyl)amino)piperidine-4-carbonitrile

Produkt 1

HCID 705871-Benzyl-4-[(4-chlorophenyl)amino]piperidine-4-carboxamideAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

To 1-Benzyl-4-(4-chloro-phenylamino)-piperidine-4-carbonitrile (1.97 g, 6.05 mmol) was added concentrated sulfuric acid (50 ml). The reaction stirred at room temperature as an orange homogeneous solution. After 24 hours the reaction was cooled to 0° C. and very slowly poured into concentrated ammonium hydroxide in ice. The precipitate was filtered and washed with water to give a white solid (202 mg, 71%).

Aufarbeitung

  1. temperatureAfter 24 hours the reaction was cooled to 0° C.
  2. filtrationThe precipitate was filtered
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-472db5c21c164fca93c386677e549843
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653096B2

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