Sodium Chloride → 5-(2-Cyanobutanoyl)thiophene-2-carbohydrazide

HRID 2425941Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2425941
[C:1]([CH:3]([CH2:15][CH3:16])[C:4]([C:6]1[S:10][C:9]([C:11](OC)=[O:12])=[CH:8][CH:7]=1)=[O:5])#[N:2].[OH-].[K+].O.[NH2:20][NH2:21].[Cl-].[Na+]>CO>[C:1]([CH:3]([CH2:15][CH3:16])[C:4]([C:6]1[S:10][C:9]([C:11]([NH:20][NH2:21])=[O:12])=[CH:8][CH:7]=1)=[O:5])#[N:2]

Komponenten

6

Edukt 4

HCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 67087195Methyl 5-(2-cyanobutanoyl)thiophene-2-carboxylate

Produkt 1

HCID 670873785-(2-Cyanobutanoyl)thiophene-2-carbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

Methyl 5-(2-cyanobutyryl)thiophene-2-carboxylate (213 mg, 0.90 mmol) in methanol was stirred with 0.1 M potassium hydroxide in methanol (9.0 mL, 0.90 mmol) at room temperature for 10 minutes and then with hydrazine monohydrate (225 mg, 4.50 mg) at 80° C. for 6 hours. After addition of saturated aqueous sodium chloride, the reaction solution was extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product.

Aufarbeitung

  1. extractionthe reaction solution was extracted with ethyl acetate
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9b5ebb64dfaa4e4ea0cc52ddc7ad69e1
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968542B2

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