5-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione → Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

HRID 2426866

Reaktionsgleichung

Reaktionsgleichung von HRID 2426866
C([N:8]1[CH2:12][CH:11]2[C:13](=[O:17])[NH:14][C:15](=[O:16])[CH:10]2[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[C:13]1(=[O:17])[CH:11]2[CH2:12][NH:8][CH2:9][CH:10]2[C:15](=[O:16])[NH:14]1

Komponenten

4

Edukt 1

HCID 45649025-Benzyl-octahydropyrrolo(3,4-c)pyrrole-1,3-dione

Produkt 1

HCID 21476587Perhydropyrrolo(3,4-c)pyrrole-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution 5-benzyl-tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione, (11.5 g; 49.9 mmol) in ethanol (200 ml) is placed in a ml autoclave and palladium-on-charcoal (5%; 2 g; 0.9 mmol) is then added. After having purged the reactor with nitrogen, the autoclave is placed under 58 bars of hydrogen at 70° C. for 16 hours. After returning to 20° C., filtration and washing of the catalyst, evaporation is carried out under reduced pressure and the solid obtained is then recrystallized from methanol (100 ml) and drying is carried out under reduced pressure at constant weight. Perhydropyrrolo[3,4-c]pyrrole-1,3-dione, (3.6 g) is isolated, the characteristics of which are as follows:

Aufarbeitung

  1. additionis then added
  2. customAfter having purged the reactor with nitrogen
  3. customAfter returning to 20° C.
  4. filtrationfiltration
  5. washwashing of the catalyst, evaporation
  6. customthe solid obtained
  7. customis then recrystallized from methanol (100 ml)
  8. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-f93aa7a6574345048f6373726ffc03c4
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968566B2

Verknüpfte Notizen

Wird geladen…