Water → 3-(2-Hydroxyacetyl)benzonitrile

HRID 2427147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2427147
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=[O:4].[OH2:13]>C(#N)C>[OH:13][CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=[O:4]

Komponenten

4

Edukt 2

HCID 962WaterHCID 27358673-(2-Bromoacetyl)benzonitrile

Produkt 1

HCID 184047733-(2-Hydroxyacetyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 776 mg of 3-(2-bromoacetyl)benzonitrile in acetonitrile (5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min) The same experiment is realized a second time with 976 mg. All the vials are collected, extracted with ethyl ether, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Aufarbeitung

  1. customAll the vials are collected
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-cf3cc6f3e75546cb957bc0c7f0907401
Quelldatensatz
uspto-grants-2011_06
Patentnummer
US07968581B2

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